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Ye-Qi
Liu, Ph.D. - Publications
1. Liu
YQ, Horio Y, Mizuguchi H, Fujimoto K, Imamura I Abe Y,
and Fukui H (1992) Re-examination of [3H]mepyramine binding assay
for histamine H1 receptors using quinine. Biochem. Biophys. Res.
Commun. 189: 378-381.
2.
Fujimoto K, Horio H, Sugama K, Liu YQ, and Fukui
H (1993) Genomic cloning of the rat histamine H1 receptor. Biochem.
Biophys. Res. Commun. 190: 294-301.
3.
Liu YQ, (1993) Regulation of histamine H1 receptor
by protein kinase C. Med. J. Osaka Univ. 45: 165-177.
4. Abe
Y, Ogino S, Irifune M, Imamura I, Liu YQ, Fukui
H, and Matsunaga T (1993) Histamine content, synthesis and degradation
in nasal mucosa and lung of gunea-pig treated with toluene diisocyanate
(TDI). Clin. Exp. Allergy 23: 512-517.
5.
Horio Y, Liu YQ, Ito S, and Fukui H (1993) Desensitization
of histamine H1 receptor by inhibitors of phosphorylase. Bull.
Jpn. Neurochem. Soc. 32: 272-273.
6. Liu
YQ, Horio Y, Fujimoto K, and Fukui H (1994) Dose the
[3H]mepyramine binding site represent the histamine H1 receptor?
Re-examination of the histamine H1 receptor with quinine. J. Pharmacol.
Exp. Ther. 286: 959-964.
7. Fukui
H, Fujimoto K, Mizuguchi H, Liu YQ, Sakamoto
K, Horio Y, and Ito S. (1994) Molecular cloning of human histamine
H1 receptor gene and up-regulation of the receptor by phorbol
ester. Therap. Res. 15 (Sup I): 218-228.
8.
Fukui H, Mizuguchi H, Liu YQ, Wang NP, Hayashi
H, Kangawa K, Wakamiya T, Leurs R, Shiba T, and Matsuo H. (1995)
Purification and characterization of [3H]mepyramine (histamine
H1 antagonist)-binding protein from rat liver: a highly homologous
protein with cytochrome P450 2D. J. Biochem. 17: 993-998.
9. Liu
YQ and Uyeda K (1996) A mechanism of fatty acid inhibition
of glucose utilization in liver: role of xylulose 5-P. J. Biol.
Chem. 271: 8824-8830.
10. Liu
YQ and Uyeda K (1996) A mechanism of regulation of hepatic
Fru 2,6-P2 concentration upon refeeding: involvement of xylulose
5-P and cyclic-AMP. Biochem. Biophys. Res. Commun. 221-554-558.
11. Liu
YQ, Tornheim K and Leahy JL (1998) Fatty acid-induced
ß-cell hypersensivity to glucose: increased phosphofructokinase
activity and lowered glucose-6-phosphate content. J. Clin. Invest.
101:1870-1875.
12. Liu
YQ, Tornheim K and Leahy JL (1998) Shared biochemical
properties of glucotoxicity and lipotoxicity in islets decrease
citrate synthase activity and increase phosphofructokinase activity.
Diabetes 47: 1889-1893.
13. Liu
YQ, Tornheim K and Leahy JL (1999) Glucose-fatty acid
cycle to inhibit glucose utilization and oxidation is not operative
in fatty-acid cultured islets. Diabetes 48: 1747-1753.
14. Liu
YQ, Nevin P, and Leahy JL (2000) Mechanism of ß-cell
adaptation that preserves normoinsulinemia and normoglycemia in
60% pancreatectomy rats. Am. J. Physiol. 278: E68-E73.
15.
Liu YQ, Montanya E. and Leahy JL (2001) Increased islet
DNA synthesis and glucose-derived lipid and amino acid production
in association with ß-cell hyperproliferation in normoglycemic
60% pancreatectomy rats. Diabetologia 44: 1026-1033.
16. Jetton
TL, Liu YQ, Trotman WE, Nevin PW, Sun XJ, and
Leahy JL (2001) Enhanced expression of insulin receptor substrate-2
and activation of protein kinase B/Akt in regenerating pancreatic
duct epithelium of 60 % partial pancreatectomy rats. Diabetologia
44: 2056-2065.
17. Harper
ME, Antoniou A, Villalobos-Menuey E, Russo A, Trauger R, Vendemelio
M, George A, Bartholomew R, Carlo D, Shaikh A, Kupperman J, Newell
EW, Bespalov IA, Wallace SS, Liu YQ, Rogers JR,
Gibbs GL, Leahy JL, Camley RE, Melamede R, Newell MK (2002) Characterization
of a novel metabolic strategy used by drug-resistant tumor cells.
FASEB J. 16:1550-7.
18. Liu
YQ, Jotton TL, and Leahy JL (2002) Beta-cell adaptation
to insulin resistance: Increased pyruvate carboxylase activity
and anaplerosis in islets of Zucker fatty rats. J. Biol. Chem.
277:39163-8.
19.
Liu YQ, Moibi JA, and Leahy JL (2004) Chronic
high glucose lowers pyruvate dehydrogenase activity in islets
through enhanced production of long-chain Acyl-CoA. Prevention
of impaired glucose oxidation by enhanced pyruvate recycling through
the malate-pyruvate shunt. J. Biol. Chem. 279:7470-5.
20. Liu
YQ, Han J, Epstein PN, and Long YS (2005) Enhanced rat
ß cell proliferation in 60% pancreatectomized islets by
increasing glucose metabolic flux through pyruvate carboxylase
pathway. Am. J. Physiol. 288: E471-E478.
21. Han
J, Xu J, Epstein PN and Liu YQ (2005) Long-term
effect of maternal obesity on offspring pancreatic beta cells:
reduced beta cell adaptation to high glucose and high fat diet
challenges in adult female mouse offspring. Diabetologia. 48:1810–1818.
22.
Xu J, Han J, Epstein PN and Liu YQ (2006) Regulation
of PDK mRNA by high fatty acid and glucose in pancreatic islets.
Biochem. Biophys. Res. Commun. 344:827-833.
23.
Han J, Xu J, Long YS, Epstein PN and Liu YQ (2007)
Maternal diabetes impairs pancreatic beta cell function in the
offspring. Am. J. Physiol. 293 E228-E236.
24. Xu
J, Han J, Long YS, Epstein PN and Liu YQ: Pyruvate
carboxylase plays a key role in insulin secretion and cell proliferation
in pancreatic beta cells. Submitted.
25.
Xu J, Han J, Long YS, Epstein PN and Liu YQ:
Malic enzyme in mouse islets: an important component of pyruvate-malate
shuttle for insulin secretion. Submitted.
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