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Functions
of Cyclophilin Cpa1 and Cpa2 |
C. neoformans Cpa1 and Cpa2 are cyclophilins that are
important for growth and virulence. Cpa1, in particular, is required
for growth at 39°C. To further study functions of Cpa1, we
have employed a yeast two-hybrid screen to identify proteins that
interact with Cpa1. Our ongoing efforts to functionally characterize
proteins, including sucrose invertase and trahalose phosphatase,
that interact with Cpa1, will allow us to test the hypothesis
that Cpa1 plays a role in regulating carbohydrate metabolism in
the fungus.
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