| |
Seth H. Pincus, M.D. - Publications
1. Pincus, S. H., Bianco, C. B., and Nussenzweig,
V. N.: Increased proportion of complement receptor lymphocytes
in the peripheral blood of patients with chronic lymphatic leukemia.
Blood XL: 303-310, 1972.
2. Nussenzweig, V. N. Bianco, C. B., Eden,
A., and Pincus, S. H.: Interaction between soluble or cell bound
immune complexes with B lymphocytes. Proc. First International
Conference of Hematology Society, 1972.
3. Rogentine, G. N., Doherty, C. M., and Pincus,
S. H.: Increase in titer of the naturally occurring human antibody
to neuraminidase treated lymphocytes after influenza. J.Immunol.
119: 1652-1654, 1977.
4. Cowing, C. O., Pincus, S. H., Sachs, D.
H., and Dickler, H. B.: A subpopulation of adherent accessory
cells bearing both I-A and I-E or C subregion antigens is required
for antigen specific murine T lymphocyte proliferation. J.Immunol.
121: 1680-1686, 1978.
5. Pincus, S. H., Sachs, D. H., and Dickler,
H. B.: The production of antisera specific for idiotype(s) of
murine anti-(T,G)-A--L antibodies. J.Immunol. 121: 1422-1427,
1978.
6. Pincus, S. H., Singer, A., Hodes, R. J.,
Sachs, D. H., and Dickler, H. B.: Anti (T,G)-A--L idiotypes, initial
studies of genetic control and cellular expression. In Cells of
Immunoglobulin Synthesis. Academic Press, 1979, pp. 371-380.
7. Ju, S.-T., Pincus, S. H., Pierres, M., Stocks,
C. J., and Dorf, M. E.: Idiotypic relationships between antibodies
binding the synthetic polypeptides GAT and (T,G)--A--L. J.Immunol.
128: 545-550, 1982.
8. Pincus, S. H.: A sense of self. Perspec.Biol.Med.
267: 30-38, 1982.
9. Pincus, S. H., Ewing, L. P., and Stocks,
C. J.: Anti-(T,G)-A--L hybridomas. Fine specificity and idiotypic
characterization. Mol. Immunol. 9: 1551-1559, 1982.
10. Pincus, S. H.: The role of the major histocompatibility
complex in the regulation of the immune response. In Daynes, R.
A. (Ed.): Clinicaland BasicPhotoimmunology. CRC Press, 1983, pp.
127-138.
11. Christensen, R. D., Rothstein, G., Hill,
H. R., and Pincus, S. H.: The effect of hybridoma antibody on
the neutrophil system in experimental type III group B streptococcal
sepsis. Pediatr.Res. 17: 795-799. 1983.
12. Iwasa, S. Pincus, S. H., Saito, E., Patritti-Laborde,
N., and Odell, W. D.: A simple and sensitive solid-phase radioimmunoassay
for the assay of human TSH antibody. Appl.Biochem.Biotechnol.
8: 305-314, 1983.
13. Shigeoka, A. O., Pincus, S. H., Rote, N.
S., and Hill, H. R.: Protective effect of hybridoma type specific
antibody against group B streptococcal infection. J.Infect.Dis.
149: 363-372, 1984.
14. Ju, S.-T., Pincus, S. H., Kunar, J., and
Dorf, M. E.: Immunoselection of B-cell hybridomas. I. The role
of heavy and light chains for the expression of CGAT idiotype
and GAT binding activity. J.Immunol. 132: 2485-2490, 1984.
15. Pincus, S. H., Watson, W. R., Ewing, L.
R., Stocks, C. J., Harris, S. B., and Rollins, D. R.: Monoclonal
anti-digoxin antibodies: genotypic and phenotypic characterization.
LifeSci. 35: 433-440, 1984.
16. Shigeoka, A. O., Jensen, C., Pincus, S.
H., and Hill, H. R.: Absolute requirement for complement in monoclonal
IgM mediated protection against experimental type III group B
streptococcal infection. J.Infect.Dis. 150: 63-70, 1984.
17. Christensen, R. D., Rothstein, G., Hill,
H. R., and Pincus, S. H.: Treatment of experimental group B streptococcal
infection with hybridoma antibody. Pediatr.Res. 18: 1093-1096,
1984.
18. Pincus, S. H., Carmack, C. E., Brodeur,
P., and Riblet, R.: Antibody degeneracy in the immune response
to synthetic polypeptides. UCLA Symposia on Molecular and Cellular
Biology, New Series 18: 455-462, 1984.
19. Pincus, S. H., Ewing, L. P., Araneo, B.
A., and Ju, S.-T.: Variable regions of antibodies to synthetic
polypeptides. I. Characterization of monoclonal antiidiotope antibody.
Mol.Immunol. 22: 455-461, 1985.
20. Shigeoka, A. O., Pincus, S. H., Rote, N.
S., Pritchard, D. G., Santos, J. I., and Hill, H. R.: Monoclonal
antibody preparations for immunotherapy of experimental group
B streptococcal infection. In Christensen, P., Christensen, K.
K., Ferrari, P., and Linden, V. (Eds.): NeonatalGroupB-StreptococcalInfection.
S. Karger, Inc., Basel, 1985, pp.254-266.
21. Pincus, S. H., Clegg, D. O., and Ward,
J. R.: Characterization of T-cells bearing HLA-DR antigens in
rheumatoid arthritis. Arthritis Rheum. 28: 8-15, 1985.
22. Hill, H. R., Shigeoka, A. O., Pincus, S.
H., Christensen, R. D.: Intravenous IgG in combination with other
modalities in the treatment of neonatal infection. J. Ped. Infect.
Dis. S180-184, 1986.
23. Shigeoka, A. O., Weber, M. E., Pincus,
S. H., Pritchard, D. G., and Hill, H. R.: Type specific monoclonal
antibody enhances the local phagocytic response to group B streptococcal
infection. J. Infect. Dis. 153: 1170-1173, 1986.
24. Pincus, S. H., Pisetsky, D. S. Rosenwasser,
L. J. (Eds.) Biologically Based Immuno-modulators in the Therapy
of Rheumatic Disease. New York, Elsevier Scientific Publishing,
New York, 1987. Chapters contributed by S. H. Pincus: Introduction,
pp. 1-16; Chimeric and immobilized antibodies, pp. 229-238; Therapeutic
potential of interferons, pp. 337-342; In conclusion: A survey
of current ideas and future directions, pp. 397-400.
25. Clegg, D. O., Pincus, S. H., Zone, J. J.,
and Ward, J. R.: Circulating HLA-DR bearing T-cells. Lack of correlation
with clinical manifestations of disease activity. J. Rheumatol.
13: 870-874, 1986.
26. Carmack, C. E., and Pincus, S. H.: Variable
regions of antibodies to synthetic polypeptides. II. Analysis
of variable region gene encoding antibodies specific for (T,G)-A--L.
J. Immunol. 137: 3983-3989, 1986.
27. Shigeoka, A. O., Pritchard, D. G., Pincus,
S. H., Egan, M., and Hill, H. R.: Monoclonal or polyclonal antibody
mediated protection against group B streptococci is markedly enhanced
by fibronectin. In Kimura, Y., Kotami, S., and Shiokawa, Y. (Eds.):
Recent Advances in Streptococci and Streptococcal Diseases. U.K.,
Reed Books, 1985, pp. 290-292.
28. Pisetsky, D. S., Klatt, C., and Pincus,
S. H.: Characterization of monoclonal antibodies with specificity
for DNA and the synthetic polypeptide antigen (T,G,)-A--L. Mol.
Immunol. 24: 365-369, 1987.
29. Pincus, S. H., Ivey, R. G., and Ward, J.
R.: Genetic polymorphism within the human heavy chain variable
gene complex. In Pruzanski, W., and Seligmann, M. (Eds.): Clinical
Immunology, Amsterdam, Elsevier Scientific Pub., 1987, pp. 187-194.
30. Pincus, S. H., Shigeoka, A. O., Moe, A.
A., Ewing, L. P., and Hill, H. R.: Protective efficacy of IgM
monoclonal antibodies in experimental group B streptococcal infection
is a function of antibody avidity. J. Immunol. 140: 2779-2785,
1988.
31. Pincus, S. H.: Human immunoglobulin heavy-chain-variable
(VH) region gene families defined by hybridization with cloned
human and murine VH-genes. Hum.Immunol. 22: 199-215, 1988.
32. Brizgys, M. V., Pincus, S. H., and Rollins,
D. E.: Characterization of monoclonal antidigoxin antibodies immobilized
to a solid support. Biotechnol. Appl. Biochem. 10: 373-384, 1988.
33. Pincus, S. H.: Immunomodulation and experimental
therapies. In McCarty, D. R. (Ed.): Arthritis and Allied Conditions.
11th Ed. Philadelphia, Lea and Febiger, 1989. pp.622-645.
34. Yang, K. D., Bathras, J. M., Shigeoka,
A. O., James, J., Pincus, S. H., and Hill, H. R.: Mechanisms of
bacterial opsonization by immune globulin intravenous: correlations
of complement consumption with opsonic activity and protective
efficacy. J. Infect. Dis. 159: 701-707, 1989.
35. Pincus, S. H., Wehrly, K., and Chesebro,
B.: Treatment of HIV tissue culture infection with monoclonal
antibody-ricin A chain conjugates. J. Immunol. 142: 3070-3075,
1989.
36. Brizgys, M. V., Pincus, S., Siebert, C.
J., and Rollins, D. E.: Removal of digoxin from the circulation
using immobilized monoclonal antibodies. J. Pharm. Sci. 78: 393-398,
1989.
37. Cannon, G. W., Pincus, S. H., Emkey, R.
D., Denes, A., Cohen, S. A., Wolfe, F., Saway, P. A., Jaffer,
A. M., Weaver, A. L., Cogen, L., and Schindler, J. D.: Double-blind
trial of recombinant gamma-interferon versus placebo in the treatment
of rheumatoid arthritis. Arthritis Rheum. 32: 964-973, 1989.
38. Pincus, S. H., Cannon, G. W., and Ward,
J. R.: In vivo administration of interferon-gamma to rheumatoid
arthritis patients decreases numbers of circulating B cells. J.
Rheumatol. 17: 751-757, 1990.
39. Pincus, S. H., Wehrly, K., Tschachler,
E., Hayes, S. F., Buller, R. S., and Reitz, M.: Variants selected
by treatment of human immunodeficiency virus-infected cells with
an immunotoxin. J. Exp. Med. 172: 745-757, 1990.
40. Horgan, C., Brown, K., and Pincus, S. H.:
Alteration in heavy chain V region affects complement activation
by chimeric antibodies. J. Immunol. 145: 2527-2532, 1990.
41. Pincus, S. H., and Wehrly, K.: AZT demonstrates
anti-HIV-1 activity in persistently infected cell lines: implications
for combination chemotherapy and immunotherapy. J. Infect. Dis.
162: 1233-1238,1990.
42. Pincus, S. H.: Anti-HIV immunotoxins. In
Koff, W. C., Wong-Staal, F., and Kennedy, R. C., (Eds.): AIDS
Research Reviews, Vol. 1. New York, Marcel Dekker, Inc., 1991,
pp. 315-328.
43. Pincus, S. H., Wehrly, K., and Chesebro,
B.: Use of a focal infectivity assay for testing susceptibility
of HIV to antiviral agents. BioTechniques 10: 336-342, 1991.
44. Pincus, S. H., Cole, R. L., Hersh, E. M.,
Lake, D., Masuho, Y., Durda, P. J., and McClure, J.: Invitro efficacy
of anti-HIV immunotoxins targeted by various antibodies to the
envelope protein. J. Immunol. 146: 4315-4324, 1991.
45. Pincus, S. H., Cole, R., and Pisetsky,
D. S.: A defect in the humoral immune response to protein antigens
and haptens in immunoglobulin mu heavy-chain transgenic mice.
Mol. Immunol. 29: 801-806, 1992.
46. Pincus, S. H., Cole, R. L., Wessels, M.
R., Corwin, M. D., Kamanga-Sollo, E., Hayes, S. F., Cieplak, W.,
Jr., and Swanson, J.: Group B streptococcal opacity variants.
J. Bacteriol. 174: 3739-3749, 1992.
47. Pincus, S. H., and Carmack, C. E.: Variable
regions of antibodies to synthetic polypeptides. III. Antibodies
arising in response to administration of anti-idiotype. Mol. Immunol.
29: 811-819, 1992
48. Horgan, C., Brown, K., and Pincus, S. H.:
Effect of H chain V region on complement activation by immobilized
immune complexes. J. Immunol. 149: 127-135, 1992.
49. Horgan, C., Brown, K., and Pincus, S. H.:
Variable region differences affect antibody binding to immobilized
but not soluble antigen. Hum. Antibodies Hybridomas 3: 153-157,
1992.
50. Pincus, S. H.: Immunoregulation and experimental
therapies. In McCarty, D. J., and Koopman, W. J. (Eds.): Arthritis
and Allied Conditions: A Textbook of Rheumatology, 12th Edition.
Philadelphia, Lea and Febiger, 1993, pp. 683-710.
51. Pincus, S. H., Rosa, P. A., Spangrude,
G. J., and Heinemann, J. A.: The interplay of microbes and their
hosts. Immunol. Today 13: 471-473, 1992.
52. Pincus, S. H., and McClure, J.: Soluble
CD4 enhances the efficacy of immunotoxins directed against gp41
of the human immunodeficiency virus. Proc. Nat. Acad. Sci. USA
90: 332-336, 1993.
53. Pincus, S. H., Messer, K. G., Schwartz,
D. H., Lewis, G. K., Graham, B. S., Blattner, W. A., and Fisher,
G.: Differences in the antibody response to human immunodeficiency
virus-1 envelope glycoprotein (gp160) in infected laboratory workers
and vaccinees. J. Clin. Invest. 91: 1987-1996, 1993.
54. Horgan, C., Brown, K., and Pincus, S. H.:
Studies on antigen binding by intact and hinge-deleted chimeric
antibodies. J. Immunol. 150: 5400-5407, 1993.
55. Pincus, S. H., Cole, R. L., Kamanga-Sollo,
E., and Fischer, S. H.: Interaction of group B streptococcal opacity
variants with the host defense system. Infect. Immun. 61: 3761-3768,
1993.
56. Pincus, S. H., Messer, K. G., and Hu, S-L.:
Effect of nonprotective vaccination on antibody response to subsequent
HIV infection. J. Clin. Invest. 93: 140-146, 1994.
57. Pincus, S. H.: Immunotoxins: clinical potential
in the treatment of AIDS. Invited editorial in Clin. Immunotherapeutics
1: 89-94, 1994.
58. Pincus, S.H.: Immunotoxins. In Rosenberg,
M., and Moore, G. (Eds.): The Pharmacology of Monoclonal Antibodies,
in the monograph series Handbook of Experimental Pharmacology.
Berlin, Springer-Verlag Press, 1994, 149-178.
59. Pincus, S. H., McClure, J., and Fang, H.:
Use of anti-HIV immunotoxins as probes of the biology of HIV-infected
cells. In Proceedings of the Second International Congress on
Biological Response Modifiers, Can. J. Inf. Dis. 5: 23A-27A, 1994.
60. Abacioglu, Y. H., Fouts, T. R., Laman,
J. D., Claassen, E., Pincus, S. H., Moore, J. P., Roby,C. A.,
Kamin-Lewis, R., and Lewis, G. K.: Epitope mapping and topology
of baculovirus-expressed HIV-1 gp160 determined with a panel of
murine monoclonal antibodies. AIDS Res. Hum. Retroviruses 10:
371–381, 1994.
61. Pincus, S. H., Messer, K. G., Nara, P.
L., Blattner, W. A., Colclough, G., and Reitz, M.: Temporal analysis
of the antibody response to HIV envelope protein in HIV-infected
laboratory workers. J. Clin. Invest. 93: 2505-2513, 1994.
62. Pincus, S. H.: Is there a role for immunoconjugates
in the treatment of AIDS? Exp. Opin. Invest. Drugs 3: 799-807,
1994.
63. Pincus, S. H.: Anti-HIV immunotoxins: gp41
rather than gp120 should be the target. Int. Antiviral News 2:147-148,
1994.
64. Pincus, S. H., and Tolstikov, V. V.: Anti-human
immunodeficiency virus immunoconjugates. Adv. Pharmacol. 32: 205-247,
1995
65. Fang, H., and Pincus, S. H.: Unique insertion
sequence and pattern of CD4 expression in variants selected with
immunotoxins from human immunodeficiency virus type-1-infected
T cells. J. Virol. 69: 75-81, 1995.
66. Duensing, T. D., Fang, H., Dorward, D.
W., and Pincus, S. H.: Processing of the envelope glycoprotein
in
immunotoxin resistent cell lines chronically infected with HIV-1.
J. Virol., 69:7122-31, 1995
67. Pincus, S. H., Cole, R., Ireland, R., McAtee,
F., Fujisawa, R., and Portis, J.: Protective efficacy of non-neutralizing
monoclonal antibodies in acute infection with murine leukemia
virus. J. Virol. 69:7152-58, 1995.
68. Pincus, S.H., Wehrly, K., Cole, R., Fang,
H., Lewis, G.K., McClure, J., Conley, A.J., Wahren, B., Posner,
M.R., Notkins, A.L., Tilley, S.A., Pinter, A., Eiden, L., Teintze,
M., Dorward, D., and Tolstikov, V.V.: In vitro effects of anti-HIV
immunotoxins directed against multiple epitopes on the HIV-1 envelope
glycoprotein gp160. AIDS Research and Human Retroviruses, 12:1041-51,
1996
69. Pincus, S.H.: Therapeutic potential of
anti-HIV immunotoxins. Antiviral Research, 33:1-9, 1996
70. Tolstikov, V.V., Cole, R.L., Fang, H..
and Pincus, S.H.: The influence of endosome-destabilizing peptides
on efficacy of anti-HIV immunotoxins. Bioconjugate Chemistry,
8:38-43, 1997
71. Pincus, S.H., Messer, K.G., Cole, R., Ireland,
R., VanCott, T.C., Pinter, A., Schwartz, D.H., Graham, B.S., Gorse,
G.J. : Vaccine-specific antibody responses induced by HIV-1 envelope
subunit vaccines. J. Immunol. , 158: 3511-20, 1997.
72. Pincus, S.H., Cole, R.L., Watson-McKown,
R., Pinter, A., Honnen, W., Cole, B. Wise, K.S. Immunologic Crossreaction
between HIV-1 p17 and Mycoplasma hyorhinis variable lipoprotein.
AIDS Research and Human Retroviruses, 14:419-25, 1998
73. Pincus, S.H., Smith, M.J., Jennings, H.J.,
Burritt, J.B., Glee, P.M. Peptides that Mimic the Protective Antigen
of Group B Streptococcal Type III Capsular Polysaccharide. J.
Immunol., 160:293-98, 1998
74. Cassutt, K.J. and Pincus, S.H. Improved
Reproducibility of ELISA Using a Static Discharge
Pad. BioTechniques, 25:801-02, 1998
75. Glee, P.E., Pincus, S.H., Smith, M.J, McNamer,
D.K., Burritt, J.B., and Cutler,J.E. Peptide ligands that bind
IgM antibodies and block interaction with antigen. J. Immunol.
, 163:826-33, 1999
76. Fang, H. and Pincus, S.H., Spontaneous
activation of HIV-1 An immunotoxin resistant variant cell line.
AIDS Research and Human Retroviruses, 15:1345-49, 1999.
77. Pincus, S.H.: Targeting Drugs to HIV-Infected
Cells. in Methods in Molecular Medicine: Volume 25. Drug Targeting.
G.E. Francis, and C. Delgado eds., Humana Press, Totowa, NJ. pp
193-214, 2000
78. Pincus, S.H., Marcotte, T.K., Forsyth,
B.M., and Fang, H. In vivo testing of anti-HIV immunotoxins. In
Methods in Molecular Biology. Volume 166. Immunotoxin Methods
and Protocols, Walter A. Hall, ed., Humana Press, Totowa, NJ.,
pp. 277-294, 2001
79. Pincus, S.H., LePage, S.R., Jung, R.F.,
Massey, J.G., and Jaseja, M. Initial studies of the molecular
basis of peptide mimicry of group B streptococcal type III capsular
polysaccharide. International Reviews of Immunology, 20:221-227,
2001
80. Pincus, S.H., Fang, H., and Wilkinson R.
Anti-HIV Immunotoxins. In Biomedical Aspects of Drug Targeting,
V.R. Muzykantov and V. Torchinin, editors. Kluwer Academic Publisher,
pp403-418, 2002.
81. Schweitzer, M.H., Hill, C.L., Asara, J.M.,
Lane, W.S., and Pincus, S.H. Identification of immunoreactive
material in mammoth fossils. J. Mol. Evolution., 55:696-705, 2002
82. Pincus, S.H., Eng, L., Cooke, C.L., and
Maddaloni, M. Identification of hypoglycemia in mice as a surrogate
marker of ricin toxicosis. Comparative Medicine, 52:530-33, 2002.
83. Pincus, S.H., Fang, H., Wilkinson, R.A.,
Marcotte, T.K., Robinson, J.E., and Olson, W.C. In vivo efficacy
of anti-gp41, but not anti-gp120, immunotoxins in a mouse model
of infection. J. Immunology, 170:2236-41, 2003.
84. Johnson, M.A., Jaseja, M., Zou, W., Jennings,
H.J., Copie, V., Pinto, B.M., and Pincus, S.H. NMR studies of
carbohydrate and carbohydrate-mimetic peptides recognized by an
anti-group B streptococcus antibody. J. Biol. Chemistry, 278:
24740-52, 2003.
85. Pincus, S.H., Fang, H., Wilkinson, R.A.,
Olson, W.C., and Markotte, T.K. A modified SCID mouse model of
HIV infection with utility for testing anti-HIV therapies. AIDS
Research and Human Retroviruses, 19:901-09, 2003.
86. Maddaloni, M., Cooke, C. Wilkinson, R.,
Stout, A.V., Eng, L., and Pincus, S.H. Immunological characteristics
associated with protective efficacy of antibodies to ricin. J.
Immunology 172: 6221-28 2004.
87. Xu, L., Maresh, G., Giardina, J., and Pincus, S.H. Comparison
of different microarray data analysis programs and description
of a database for microarray data management. DNA and Cell Biology.
23:643-51, 2004.
88. Pincus, S.H. Models of HIV infection utilizing transgenic
and reconstituted immunodeficient mice. Drug Discovery Today:
Disease Models. 1:48-55, 2004
89. Schweitzer, M.H., Wittmeyer, J., Avci, R., and Pincus, S.H.
Experimental support for an immunological approach to the search
for life on other planets. Astrobiology: 5:30-47, 2005.
90. Schweitzer, M.H., Chiappe, L., Garrido, A.C., Lowenstein,
J.M., and Pincus, S.H. Molecular preservation in late Cretaceous
sauropod eggshells. Proc. Royal Soc.,
Biol. Sci. 272:775-84, 2005.
|
