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Group B Streptococci
Our laboratory has been studying the interaction of group B streptococci
(GBS) with the host immune system for many years. Initial studies
focused on the development of monoclonal
antibodies to GBS that provide passive protection to infection.
We are currently studying two aspects of the GBS host-pathogen
interaction. The first set of studies examines opacity
phase variation and its effects on the interaction between
host and GBS. The second set of studies utilizes peptide
mimetics of GBS carbohydrate antigens as potential antigens
for a GBS vaccine. These studies examine the stuctural basis fo
this unusual form of biological mimicry.
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