Crystal structure of furin
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Furin
and
HIV Env
|
HIV envelope gp120 and gp41
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Furin is a member of a family of proprotein convertases (PPCs)
responsible for the maturation of various cellular proteins. HIV
also uses this enzyme and related PPCs to cleave its envelope
precursor protein, gp160, into the mature forms gp120 (surface)
and gp41 (transmembrane) if this cleavage does not occur HIV is
not infectious. We are studying the effects of furin inhibitors
on HIV infection.
Presentation
describing this work.
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