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Michael S. Lan, Ph.D. - Publications
1. Hseu, T.H., Lan, M.S. and
Yang, M.D.: Cyanate from alkaline hydrolysis of cyanogen bromide-activated
polysaccharides. Anal. Biochem.116:181-184, 1981.
2. Wang, J.L., Tang, C.P., Hseu, T.H. and Lan, M.S.: The crystal structure of tert-butyl carbamate.
Proc. Natl. Sci. Counc. ROC, 6:162-165, 1982.
3. Metzgar, R.S., Rodriguez, N., Finn, O.J.,
Lan, M.S., Daasch, V.V., Fernsten, P.D., Meyers,
W.C., Sindelar, W.F., Sandler, R.S. and Seigler, H.F.: Detection
of a pancreatic cancer associated antigen (DU-PAN-2 antigen) in
serum and ascites of patients with adenocarcinoma. Proc. Natl.
Acad. Sci. USA 81:5242-5246, 1984.
4. Metzgar, R.S., Mahvi, D.M., Borowitz, M.J.,
Lan, M.S., Meyers, W.C., Seigler, H.F. and Finn,
O.J.: DU-PAN-2: A pancreatic adenocarcinoma associated antigen.
In Monoclonal Antibodies and Cancer Therapy (Alan R. Liss), pp.
63-74, 1985.
5. Lan, M.S., Finn, O.J.,
Fernsten, P.D. and Metzgar, R.S.: Isolation and properties of
a
human pancreatic adenocarcinoma-associated antigen, DU-PAN-2.
Cancer Res.
45:305-310, 1985.
6. Lan, M.S., Bast, R.C. Jr.,
Colnaghi, M.I., Knapp, R.C., Colcher, D., Schlom, J.
and Metzgar, R.S.: Co-expression of human cancer associate epitopes
on mucin
molecules. Int. J. Cancer 39:68-72, 1987.
7. Lan, M.S., Khorrami, A.,
Kaufman, B. and Metzgar, R.S.: Molecular characterization of a
mucin-type antigen associated with human pancreatic cancer. J.
Biol. Chem. 262:12863-2870, 1987.
8. Metzgar, R.S., Hollingsworth, M.A., Borowitz,
M.J., Kim, Y.W. and Lan, M.S.:
Monoclonal antibody assay for pancreatic cancer. In Cancer Diagnosis
in vitro using monoclonal antibodies (New York and Basel: Marcel
Dekker, Inc.), pp. 169-193, 1988.
9. Haviland, A.E., Borowitz, M.J., Killenberg,
P.G., Lan, M.S. and Metzgar, R.S.: Detection
of an oncofetal antigen (DU-PAN-2) in the sera of patients with
non-malignant hepatobiliary diseases and hepatomas. Int. J. Cancer
41:789-793, 1988.
10. Haviland, A.E., Borowitz, M.J.,
Lan, M.S., Kaufman, B., Khorrami, A., Phelps, P.C. and
Metzgar, R.S.: Aberrant expression of monoclonal antibody-defined
colonic mucosal antigens in inflammatory bowel disease. Gastroenterology
95:1302-1311, 1988.
11. Metzgar, R.S.,Lan, M.S.,
Kim, Y.W., Koriwchak, M.J., Mullins, T.D. and
Hollingsworth, M.A.: DU-PAN-2 mucin type differentiation antigen
of normal and malignant pancreatic ductal cells. Prog. Clin. Biol.
Res. 288: 53-61, 1989.
12. Lan, M.S. and Metzgar,
R.S.: Molecular studies of a pancreatic tumor mucin,
DU-PAN-2. In Human Tumor Antigens and Specific Tumor Therapy,
UCLA
Symposia on Molecular and Cellular Biology, Vol. 99 (Alan R. Liss,
Inc.), pp. 1-9,
1989.
13. Barnd, D.L., Lan, M.S.,
Metzgar, R.S. and Finn, O.J.: Specific, MHC-unrestricted recognition
of tumor-associated mucins by human cytotoxic T cells. Proc. Natl.
Acad. Sci. USA 86:7159-7163, 1989.
14. Lan, M.S., Hollingsworth,
M.A. and Metzgar, R.S.: Polypeptide core of a human pancreatic
tumor mucin antigen. Cancer Res. 50:2997-3001, 1990.
15. Hollingsworth, M.A., Lan, M.S.,
Batra, S.K., Qi, W-N, Mullins, T.D. and Metzgar, R.S.: Mucin antigens
and genes of pancreatic tumors. Proc. Amer. Assoc. Cancer Res.
31:482-484, 1990.
16. Lan, M.S., Batra, S.K.,
Qi, W-N., Metzgar, R.S. and Hollingsworth, M.A.: Cloning
and sequencing of a human pancreatic tumor mucin cDNA. J. Biol.
Chem. 265:15294-
15299, 1990.
17. Goto, Y., DeSilva, M.G., Toscani, A., Prabhakar,
B.S., Notkins, A.L. and Lan, M.S: A novel human insulinoma-associated
cDNA, IA-1, encodes a protein with "zinc-finger" DNA
-binding motifs. J. Biol. Chem. 267:15252-15257, 1992.
18. Lan, M.S., Russell, E.K., Lu, J., Johnson,
B.E. and Notkins, A.L.: IA-1, A new marker
for neuroendocrine differentiation in human lung cancer cell lines.
Cancer Res. 53:4169-
4171, 1993.
19. Lan, M.S., Lu, J., Goto, Y. and Notkins,
A.L.: Molecular cloning and identification of a receptor type
protein tyrosine phosphatase, IA-2, from human insulinoma. DNA
& Cell Biology 13:505-514, 1994.
20. Lan, M.S., Kajiyama, W., Donadel, G., Lu,
J., and Notkins, A.L.: cDNA sequence and
genomic organization of mouse secretin. Biochem. Biophys. Res.
Commun. 200:1066-
1071, 1994.
21. Lan, M.S., Li, Q., Lu, J., Modi, W.S. and
Notkins, A.L.: Genomic organization, 5'-upstream sequence and
chromosomal localization of an insulinoma-associated intronless
gene, IA-1. J. Biol. Chem. 269:14170-14174, 1994.
22. Lu, J., Notkins, A.L. and Lan, M.S.: Isolation,
sequence and expression of a novel mouse brain cDNA, mIA-2, and
its relatedness to members of the protein tyrosine phosphatase
family. Biochem. Biophys. Res. Commun. 204:930-936, 1994.
23. DeSilva, M.G., Lu, J., Donadel, G., Modi,
W.S., Xie, H., Notkins, A.L. and Lan, M.S.: Characterization and
chromosomal localization of a new protein disulfide isomerrase,
PDIp, highly expressed in human pancreas. DNA & Cell Biology
15:9-16, 1996.
24. Lu, J., Li, Q., Xie, H., Chen, Z.J., Borovitskaya,
A.E., Maclaren, N.K., Notkins, A.L., and Lan, M.S.: Identification
of a second transmembrane protein tyrosine phosphatase, IA-2b,
as an autoantigen in IDDM: Precursor of the 37 kDa tryptic fragment.
Proc. Natl. Acad. Sci. USA 93:2307-2311, 1996.
25. DeSilva, M.G., Jun, H., Yoon, J.W., Notkins,
A.L., and Lan, M.S.: Autoantibodies to IA-2 not detected in NOD
mice or BB rats. Diabetologia 39: 1237-1238, 1996.
26. Lan, M.S., Wasserfall, C., Maclaren, N.K.,
and Notkins, A.L. IA-2, a transmembrane protein of the protein
tyrosine phosphatase family, is a major autoantigen in IDDM. Proc.
Natl. Acad. Sci. USA 93: 6367-6370, 1996.
27. Lan, M.S., Modi, W.S., Xie, H., and Notkins,
A.L.: Assignment of the IA-2 gene
encoding an autoantigen in insulin-dependent diabetes mellitus
to chromosome 2q35.
Diabetologia 39: 1001-1003, 1996.
28. Notkins, A.L., Lu, J., Li, Q., VanderVegt,
F.P., Wasserfall, C., Maclaren, N.K., and Lan, M.S.: IA-2 and
IA-2b are major autoantigens in IDDM and the precursors of the
40 kDa and 37 kDa tryptic fragments. J. Autoimmun. 9: 677-682,
1996.
29. Xie, H., Notkins, A.L., and Lan, M.S.:
IA-2, a transmembrane protein tyrosine phosphatase, is expressed
in human lung cancer cell lines with neuroendocrine phenotype.
Cancer Res. 56: 2742-2744, 1996.
30. DeSilva, M.G., Notkins, A.L., and Lan, M.S.: Molecular characterization of a pancreas-specific protein
disulfide isomerase, PDIp. DNA & Cell Biology. 16: 269-274,
1997.
31. Zhang, B., Lan, M.S., and Notkins, A.L.:
Autoantibodies to IA-2 in insulin-dependent diabetes mellitus:
location of major antigenic determinants. Diabetes 46: 40-43,
1997.
32. Hawa, M.I., Rowe, R.E., Lan, M.S., Notkins,
A.L., Pozzili, P., Christie, M.R., and Leslie, R.D.G.: Value of
antibodies to islet protein tyrosine phosphatse-like molecule
in predicting type 1 diabetes. Diabetes 46: 1270-1275, 1997.
33. Li, Q., Borovitskaya, A.E., DeSilva, M.G.,
Wasserfall, C., Maclaren, N.K., Notkins, A.L., and Lan, M.S.:
Autoantigens in insulin-dependent diabetes mellitus : molecular
cloning and characterization of human IA-2b. Proc. Assoc. Amer.
Physicians 109: 440-452, 1997.
34. Notkins, A.L., Zhang, B.W., Matsumoto,
Y., and Lan, M.S.: Comparison of IA-2 with IA-2b and with six
other members of the protein tyrosine phosphatase family: recognition
of antigenic determinants by IDDM sera. J. Autoimmun. 10: 245-250,
1997.
35. Ramiya, V.K., Lan, M.S., Wasserfall, C.H.,
Notkins, A.L., and Maclaren, N.K.
Immunization therapies in the prevention of diabetes. J. Autoimmun.
10: 287-29, 1997.
36. Xie, H., Zhang, B., Matsumoto, Y., Li,
Q., Notkins, A.L., and Lan, M.S.:
Autoantibodies to IA-2 and IA-2b in IDDM recognize conformational
epitopes: location of the 37 and 40 kDa fragments determined.
J. Immunol. 159: 3662-3667, 1997.
37. Li, Q., Notkins, A.L. and Lan, M.S.: Molecular
characterization of the promoter region
of a neuroendocrine tumor marker, IA-1. Biochem. Biophys. Res.
Commun. 236: 776
781, 1997.
38. Leiter, E.H., Tsumura, T., Serreze, D.V.,
Chapman, H.D., Rabin, D.U., Lan, M.S., and Notkins, A.L.: Mapping
to chromosomes 1 and 12 of mouse homologs of human protein tyrosine
phosphatase, receptor-type, related genes encoding pancreatic
beta cell autoantigens. Mammal. Genome 8: 949-950, 1997.
39. Ellis, T.M., Schatz, D., Lan, M.S., Ottendorfer,
E., Wasserfall, C., Notkins, A.L., Maclaren, N.K., and Atkinson,
M.A.: Relationship between humoral and cellular immunity to insulinoma
associated protein-2 (IA-2) in IDDM. Diabetes 47: 566-569, 1998.
40. Donadel, G., Marinos, N., DeSilva, M.G.,
Lu, J., Notkins, A.L., and Lan, M.S.: Molecular cloning and characterization
of a highly basic protein, IA-4, expressed in pancreatic islets
and brain. Neuroendocrinology 67: 190-196, 1998.
41. Lu, J., Li, Q., Donadel, G., Notkins, A.L.,
and Lan, M.S.: Profile and differential expression of protein
tyrosine phosphatases in mouse pancreatic islet tumor cell lines.
Pancreas 16: 515-520, 1998.
42. Chen, Q.Y., Lan, M.S., She, J.X., and Maclaren,
N.K.: The gene responsible for autoimmune polyglandular syndrome
type 1 maps to chromosome 21q22.3 in US patients. J. Autoimmun.
11: 177-183, 1998.
43. Notkins, A.L., Lan, M.S., Leslie, R.D.G.:
IA-2 and IA-2b: The immune response in IDDM. Diabetes/Metabolism
Reviews 14: 85-93, 1998.
44. Xie, H., Deng, Y.J., Notkins, A.L., and
Lan, M.S.: Expression, characterization, processing and immunogenicity
of an insulin-dependent diabetes mellitus autoantigen, IA-2 in
Sf-9 cells. Clin. Exp. Immunol. 113: 367-372, 1998.
45. Seissler, J., de Sonnaville, J.J., Morgenthaler,
N.G., Steinbrenner, H., Khoo-Morgenthaler, U.Y., Lan, M.S., Notkins,
A.L., Heine, R.J., and Scherbaum, W.A.: Immunological heterogeneity
in type 1 diabetes: presence of distinct autoantibody patterns
in patients with acute onset and slowly progressive disease. Diabetologia
41: 891-897, 1998.
46. Lan, M.S., Mason, A., Coutant, R., Chen,
Q.Y., Vargas, A., Rao, J., Gomez, R.,
Chalew, S., Garry, R., and Maclaren, N.K.: HERV-K10s and immune
mediated (type 1) dabetes. Cell 95: 14-16, 1998.
47. Xie, J.P., Zhang, B., Lan, M.S., and Notkins,
A.L.: Genomic structure and promoter
sequence of the insulin-dependent diabetes mellitus autoantigen,
IA-2. Genomics 54:
338-343, 1998.
48. Lan, M.S., and Maclaren, N.K.: Cryptic
epitope and autoimmunity.
Diabetes/Metabolism Reviews 14: 333-334, 1998.
49. Maclaren, N., Lan, M., Coutant, R., Schatz,
D., Silverstein, J., Muir, A., Clare-Salzer, M., She, J.X., Malone,
J., Schwartz, S., Quattrin, T., DeSilva, M., VanderVegt, P., Notkins,
A., and Krischer, J.: Only multiple autoantibodies to islet cells,
insulin, GAD65, IA-2 and IA-2b predict type 1 diabetes in relatives.
J. Autoimmun. 12: 279-287, 1999.
50. Chen, Q.Y., Nadell, D., Zhang, X.Y., Kukreja,
A., Huang, Y.J., Wise, J., Svec, F., Richards, R., Friday, K.E.,
Vargas, A., Gomez, R., Chalew, S., Lan, M.S., Tomer, Y., and Maclaren,
N.K. The human leukocyte antigen HLA DRB3*020/DQA1*0501 haplotype
is associated with Graves’ disease in African Americans.
J. Clin. Endo. & Metab. 85: 1545-1549, 2000.
51. Zhu, M., Mizuno, A., Noma, Y., Murakami,
T., Kuwajima, M., Shima, K., and Lan, M.S.: Defective morphogenesis
and functional maturation in fetal islet-like cell clusters from
OLETF rat, a model of NIDDM. Int. J. Experimental Diabetes Res.
1: 289-298, 2001.
52. Taheri, F., Ochoa, J.B., Faghiri, Z., Culotta,
K., Park, H.J., Lan, M.S., Zea, A.H., and Ochoa, A.C.: L-Arginine
regulates the expression of the T cell receptor ? chain (CD3zeta)
in Jurkat cells. Clinical Cancer Res. 7 (3 Suppl): 958s-965s 2001.
53. Klappa, P., Freedman, R.B., Langenbuch,
M., Lan, M.S., Robinson, G.K., and
Ruddock, L.W.: The pancreas-specific protein disulphide isomerase
PDIp interacts with a hydroxyaryl group in ligands. Biochem. J.
354: 553-559, 2001.
54. Goswami, R., Kochupillai, N., Gupta, N.,
Kukreja, A., Lan, M.S., Maclaren, N.K.: Islet
cell autoimmunity in youth onset diabetes mellitus in northern
India. Diabetes Res. Clin.
Pract. 53: 47-54, 2001.
55. Breslin, M.B., Zhu, M., Notkins, A.L. and
Lan, M.S.: Neuroendocrine transcription
factor, IA-1, is a transcriptional repressor and contains a specific
DNA binding domain:
identification of consensus IA-1 binding sequence. Nucleic Acids
Res. 30: 1038-1045,
2002.
56. Zhu, M., Breslin, M.B., and Lan, M.S.:
A novel zinc-finger cDNA, IA-1, expression is
associated with rat AR42J cells differentiation into insulin-positive
cells. Pancreas, 24:
139-145, 2002.
57. *Saeki, K., *Zhu, M., *Kubosaki, A., Xie,
J., Lan, M.S., and Notkins, A.L. (*These
authors contribute equally to the work): Targeted disruption of
the protein tyrosine
phosphatase-like molecule, IA-2, results in alterations in glucose
tolerance tests and
insulin secretion. Diabetes 51: 1842-1850, 2002.
58. Xie, J., Cai, T., Zhang, H., Lan, M.S.,
and Notkins, A.L.: The zinc-finger transcription
factor INSM1 is expressed during embryo development and interacts
with the Cbl
associated protein. Genomics 80: 54-61, 2002.
59. Maclaren, N.K., Lan, M.S., Schatz, D.,
Malone, J., Notkins, A.L., and Krischer, J.:
Multiple autoantibodies as predictors of type 1 diabetes in a
general population.
Diabetologia, 46: 873-874, 2003.
60. Chen, Q.Y., Jackson, N., Vargas, A., Chalew,
S., Rao, J., Batzer, M., Lan, M.S.,
Chang, Y.H., Mokhashi, M., and Liu, D.: Identification of three
genomic haplotypes 5’ to
the human CD1D gene and their distribution in four ethnic groups.
Tissue Antigens, 62:
442-448, 2003.
61. Breslin, M.B., Zhu, M., and Lan, M.S.:
NeuroD1/E47 regulates the E-box element of
a novel zinc-finger transcription factor, IA-1, in developing
nervous system. J. Biol.
Chem., 278: 38991-38997, 2003.
62. Chang, Y.H., Shiau, M.Y., Tsai, S.T., and
Lan, M.S., Autoantibodies against IA-2,
GAD, and Topoisomerase II in Type 1 Diabetic Patients. Biochem.
Biophys. Res.
Commun., 320: 802-809, 2004.
63. Conn, K.J., Gao, W., McKee, A., Lan, M.S.,
Ullman, M.D., Eisenhauer, P.B., Fine,
R.E., and Wells, J.M.: Identification of the protein disulfide
isomerase family member
PDIp in experimental Parkinson’s disease and Lewy body pathology.
Brain Res., 1022:
164-172, 2004.
64. Lan, M.S., and Muguira, M.: An effective
alternate cloning strategy for mouse
unstable genomic sequences. Biochem. Biophys. Res. Commun., 330:
641-
644, 2005.
65. Liu, W.D., Wang, H.W., Muguira, M. Breslin,
M.B., and Lan, M.S.: INSM1 functions as atranscriptional repressor
of the NeuroD/?2 gene through the recruitment of cyclin D1 and
histone deacetylases. Biochem. J. 397: 169-177, 2006.
66. Pedersen, N., Pedersen, M.W., Lan, M.S.,
Breslin, M.B., Poulsen, H.S.: The
insulinoma-associated 1: a novel promoter for targeted cancer
gene therapy for small
cell lung cancer. Cancer Gene Therapy, 13: 375-384, 2006.
67. Mellitzer, G., Bonne, S., Luco, R.F., Van
De Casteele M., Lenne, N., Collombat, P.,
Mansouri, A., Lee, J., Lan, M.S., Pipeleers, D., Nielsen, F.C.,
Ferrer, J., Gradwohl, G.,
Heimberg, H. IA-1 is Ngn3-dependent and essential for differentiation
of the endocrine
pancreas. EMBO J., 25: 1344-1352, 2006.
68. Lan, M.S., Wang, H.W., Chong, J., and Breslin,
M.B.: Coupling of glucose response
element from L-type pyruvate kinase and G6Pase promoter enhances
glucose
responsive activity in hepatoma cells. Mol. Cell. Biochem., 300:
191-196, 2007.
69. Wang, H.W., Breslin, M.B., and Lan, M.S.:
Pdx-1 modulates histone H4 acetylation
and insulin gene expression in terminally differentiated ?TC-1
cells. Pancreas, 34: 248-
253, 2007.
70. Breslin, M.B., Wang, H.W., Pierce, A.,
Aucoin, R., and Lan, M.S.: Neurogenin 3
recruits CBP co-activator to facilitate histone H3/H4 acetylation
in the target gene
INSM1. FEBS Lett., 581: 949-954, 2007.
71. Nelson, B.R., Hartman, B.H., Georgi, S.A., Lan, M.S., and
Reh, T.A.: Transient
inactivation of notch signaling synchronizes differentiation of
neural progenitor cells. Dev.
Biol. 304: 479-498, 2007.
72. Wang, H.W., Muguira, M., Liu, W.D., Aucoin,
R., Breslin, M.B., and Lan, M.S.:
Identification of an INSM1 binding site in the insulin promoter:
Negative regulation of the
insulin gene transcription. Biochem. J., Submitted.
73. Lu, J. Li, G., Lan, M.S., Zhang,
S., Fan, W., Wang, H., and Lu D.: Pax4 paired
domain mediates direct protein transduction into mammalian cells.
Endocrinology,
Submitted.
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