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Antifungal
Resistance
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To explore the mechanism of echinocandin resistance in C.
neoformans in greater detail, we are examining changes in the protein composition
of the cell wall and cell membrane that occur in response to
treatment with echinocandins and other antifungals that target
cell wall synthesis. These studies will aid in the identification
of key components of cell wall biogenesis machinery in this pathogen
and will provide insight into the molecular mechanisms of antifungal
drug resistance.
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